Evaluation of an octyl group-modified Alaska pollock gelatin-based surgical sealant for prevention of postoperative adhesion

Postoperative adhesion can lead to an increase in the number of surgeries required, longer operation times, and high medical costs, resulting quality life patient being lowered. To address these clinical problems, we developed a surgical sealant with anti-adhesion properties for prevention postoperative following application large intestine surface. The was composed octyl (C8) group-modified Alaska pollock-derived gelatin (C8-ApGltn) poly(ethylene)glycol-based 4-armed crosslinker (4S-PEG) (C8-ApGltn/4S-PEG sealant). Hydrophobic modification ApGltn molecule C8 groups effectively enhanced both burst strength on surface bulk modulus. An vitro test indicated that cured C8-ApGltn/4S-PEG adhered showed low adhesive compared commercial film. Besides, inhibited albumin permeation penetration L929 fibroblasts. In vivo experiments using rat peritoneal model acted as sealing barrier target cecum also provided prevent between peritoneum cecum. sufficient cytocompatibility biodegradability therefore has potential use gastroenterological surgery.